The nuclear pore complex protein ALADIN is mislocalized in triple A syndrome
نویسندگان
چکیده
منابع مشابه
The nuclear pore complex
M OLECULAR trafficking between the nucleus and the cytoplasm of interphase eukaryotic cells occurs via the nuclear pore complexes (NPCs), 1 organelles with a roughly cylindrical shape (~,120 um in diameter and ~70-um high) that are embedded in the double-membraned nuclear envelope (NE). The NPC allows passive diffusion of ions and small molecules through an aqueous channel with a physical diame...
متن کاملThe nuclear pore complex.
Over the past years, significant progress has been made both in the analysis of the structural and molecular organization of the nuclear pore complex (NPC) and the mechanism of nuclear transport. In this minireview, I will focus on some of the recent developments in this field. Structural studies employing high resolution EM have revealed a detailed view of the three-dimensional organization of...
متن کاملThe nuclear pore complex and nuclear transport.
Internal membrane bound structures sequester all genetic material in eukaryotic cells. The most prominent of these structures is the nucleus, which is bounded by a double membrane termed the nuclear envelope (NE). Though this NE separates the nucleoplasm and genetic material within the nucleus from the surrounding cytoplasm, it is studded throughout with portals called nuclear pore complexes (N...
متن کاملTpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export
Tpr is a coiled-coil protein found near the nucleoplasmic side of the pore complex. Since neither the precise localization of Tpr nor its functions are well defined, we generated antibodies to three regions of Tpr to clarify these issues. Using light and EM immunolocalization, we determined that mammalian Tpr is concentrated within the nuclear basket of the pore complex in a distribution simila...
متن کاملProtein import through the nuclear pore complex is a multistep process
The transport of macromolecules across the nuclear envelope is mediated by the nuclear pore complex (NPC). Using cryo-electron microscopy and image processing we have mapped the interaction of three specific gold probes with the NPC and obtained projection maps of two possible intermediates in nuclear import. The probes used in these experiments were (a) mAb-414, which cross-reacts with Xenopus...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1031047100